Ca channels
CKGKGAKCSRLMYDCCTGSCRSGKC
Potent blocker of Cav2.2
ω conotoxin MVIIA (omega conotoxin MVIIA) has been isolated from the venom of the cone Conus magus. Omega-conotoxins act at presynaptic membranes, they bind and block voltage-sensitive calcium channels (VSCC). ω conotoxin MVIIA blocks N-type voltage-gated calcium channels (Cav2.2/CACNA1B). ω conotoxin MVIIA is available as analgesic drug under the name Prialt®. It blocks acute pain in patients who no longer obtain relief from opiate drugs. It is 100 to 1.000 times more potent than morphine. This toxin blocks calcium channels and disables nerves that transmit pain signals.
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