LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
- Gene name: Lyve-1
- Host: Mouse
- Label: None
- Clone: (#7F13)
- Isotype: IgG2
- Applications: WB, IHC
- Species Reactivity/Origin species: Human
- Antigen: Human recombinant LYVE-1
- Purification method: Protein G chromatography
- Reconstitution Buffer: PBS
- Buffer: PBS
- Additives/Stabilizer: None
- Form: lyophilized
- Storage: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
- Reconstitution tips: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
- NCBI GeneID: 10894
- Accession Number Protein: NP_006682
- Accession Numberm RNA: NM_006691
- Uniprot: Q9Y5Y7
- Chromosomal location: 11p15
For research use only.
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