IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant rat IL-15 is a 13.5 kDa protein consisting of 115 amino acid residues.
- Gene name: IL-15
- Host: E. coli
- Label: None
- Applications: The ED50 as determined by the dose-dependant stimulation of the proliferation of murine CTLL-2 cells is < 10 ng/ml, corresponding to a specific activity of > 1 x 105 units/mg.
- Species Reactivity/Origin species: Human, Mouse, Rat
- Purity: > 96% by SDS-PAGE & HPLC analyses
- Endotoxin levels: < 0.1 ng/µg of protein (<1EU/µg)
- Additives/Stabilizer: None
- Form: lyophilized
- MW: 13.5 kDa
- Length (aa): 115
- Protein Sequence: MNWIDVRYDL EKIESLIQFI HIDTTLYTDS DFHPSCKVTA MNCFLLELQV ILHEYSNMTL NETVRNVLYL ANSTLSSNKN VIESGCKECE ELEERNFTEF LQSFIHIVQM FINTS
- NCBI GeneID: 25670
- Accession Number Protein: NP_037261.1
- Accession Numberm RNA: NM_013129
- Uniprot: P97604
- Chromosomal location: 19q11
For research use only.
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