FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes’ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.
Working aliquots are stable for up to 3 months when stored at -20°C.
- Tested Applications: N/A
- Applications: This recombinant proteins is for research use only.
- Predicted Molecular Weight: N/A
- Physical state: Liquid
- Buffer: 0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
- Concentration: ~0.5mg/ml
- NCBI official symbol: Fto
- Accession #: Q8BGW1
- Protein GI: 81873739
- NCBI gene ID#: 26383
- NCBI official full name: fat mass and obesity associated
- NCBI organism: Mus musculus
- Peptide sequence: N/A
- SWISSPROT #: P30152
- Background Reference 1: N/A
- Background Reference 2: N/A
- Background Reference 3: N/A
- Background Reference 4: N/A
- Background Reference 5: N/A
- Source: E. coli
- Species: Mouse
- By Source: E. Coli
- By Species: Mouse
- Fusion tag: His Tag
- Sequence: Mouse FTO (aa 2-502) is fused at the N-terminus to a His-tag.
- Biology activity: N/A
- Purity: >90% (SDS-PAGE).
- Endotoxin level is less than 1EU/ µg purified protein (LAL test
- Lonza).
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