A polyclonal antibody for Caspase 3 (cleaved) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from human Caspase 3.. The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:2000), IHC (200). This Caspase 3 (cleaved) antibody is conjugated to Streptavidin.
Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts. Caspase-3 is activated in the apoptotic cell both by extrinsic (death ligand) and intrinsic (mitochondrial) pathways. The zymogen feature of caspase-3 is necessary because if unregulated, caspase activity would kill cells indiscriminately. Caspase-3 has been found to be necessary for normal brain development as well as its typical role in apoptosis, where it is responsible for chromatin condensation and DNA fragmentation. Elevated levels of a fragment of Caspase-3, p17, in the bloodstream is a sign of a recent myocardial infarction. It is now being shown that caspase-3 may play a role in embryonic and hematopoietic stem cell differentiation.
- Shipped on ice packs at +4ºC. Upon receipt keep at -20ºC.
- The gross weight ( in kg) of the package is ~1.4 kg. The net weight of the product is ~0.1 grams.
- The item is not hazardous according to both ADR and UN. Its tariff code is 3002.15.0000 (Immunological products, put up in measured doses or in forms or packings for retail sale). The UNSPSC code of the product is 12352203 (Antibodies).
This product is not for human or animal treatment or consumption. Not for use in diagnostics or therapeutics. For in vitro research use only.
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