The biological effects of interleukin 2 (IL-2) are mediated by its binding to a multi-chain cellular receptor complex. The IL-2 receptor (IL-2 R) complex consists of three glycoprotein chains. The alpha chain (IL-2 R alpha /CD25) and beta chain (IL-2 R beta /CD122) act together with the gamma chain (IL-2 R gamma /CD132) to form a high affinity receptor that transduces the signal upon IL-2 binding. Alone, IL-2 R alpha binds IL-2 with low affinity, but is unable to transduce a signal. The alpha/beta combination binds IL-2 with intermediate affinity, but is still unable to transmit a signal inside the cell. The beta/gamma complex has intermediate affinity and is capable of signaling if the concentration of IL-2 is relatively high.
- Gene name: CD25
- Host: Rat
- Label: None
- Clone: (#7G19)
- Isotype: IgG1
- Applications: IHC, FC
- Species Reactivity/Origin species: Mouse
- Antigen: Recombinant Mouse CD25 protein
- Purification method: Protein G/A chromatography
- Reconstitution Buffer: PBS (sterile)
- Buffer: PBS
- Additives/Stabilizer: None
- Form: lyophilized
- Storage: Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
- Reconstitution tips: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
- NCBI GeneID: 16184
- Accession Number Protein: NP_032393.3
- Accession Numberm RNA: NM_008367.3
- Uniprot: P01590
- Chromosomal location: 2 A2-A3
- 2 6.4 cM
For research use only.
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