9(Z),11(E),13(E)-Octadecatrienoic Acid

9(Z),11(E),13(E)-Octadecatrienoic Acid

• SMILES: C(C/C=C\C=C\C=C\CCCC)CCCCCC(O)=O
• Formula: C18H30O2

• Purity: 0.98
• CAS#: 506-23-0
• Molecular Weight: 278.43
• Bioactivity: 9(Z),11(E),13(E)-Octadecatrienoic Acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes.

For research use only.