Mirasol PRT, Navigant Biotechnologies is growing strategies that enhance the protection of blood via way of means of decreasing the pathogens observed in amassed blood.

The precise Mirasol Pathogen Reduction Technology, from Navigant Biotechnologies, applies mild and riboflavin to adjust the nucleic acids of pathogens, rendering them inactive. This is the primary unmarried generation that has been proven to inactivate pathogens in all 3 essential blood components: purple blood cells, platelets, and plasma.

Riboflavin, a non-poisonous and non-mutagenic compound, is ingested in everyday diets. In fact, riboflavin is taken into consideration critical for human health. Navigant Biotechnologies’ number one intention is to apply this generation to enhance the protection of the world’s blood supply.

Facts on riboflavin

Benefits of Mirasol PRT

Mirasol Pathogen Reduction Technology offers several key benefits including:

  • Natural compound – considered essential for human health, riboflavin is non-toxic, non-mutagenic and ingested in normal diets.
  • Simplicity – no removal of residual compounds is required.
  • Cost effectiveness – because it is an inherently simple process, overhead costs are minimized

Mirasol PRT System

Mirasol PRT device from Navigant Biotechnologies is pretty easy. Riboflavin is blended right into a blood product, that’s then uncovered to mild for a brief length of time – commonly much less than 10 minutes. This illumination reasons a chemical response that stops the DNA and RNA of the pathogen from replicating.

The nucleic acids DNA and RNA offer the commands for copying and reproducing the pathogen. Viruses, micro organism and different cells with nuclei (e.g., white blood cells) are as a result inactivated due to the fact they’re not able to copy and unfold via the body. Red blood cells, platelets, and plasma, which lack nucleic acids, aren’t harmed. When taken orally, riboflavin is commonly appeared as secure (GRAS). This designation, identified with the aid of using the U.S. Food and Drug Administration (FDA) manner a certified medical professional has deemed a substance secure for consumption. Riboflavin is a water-soluble nutrition and is without difficulty damaged down and removed with the aid of using the body.

The primary derivative of riboflavin picturegraph illumination is lumichrome. Studies have proven that publicity to lumichrome thru blood does now no longer gift a threat to transfusion patients. Further research have proven that picturegraph merchandise generated with the aid of using the Mirasol PRT System arise obviously in vivo.

Mirasol PRT device presently does now no longer require elimination of residual riboflavin or picturegraph prodcuts. This factor of Mirasol PRT makes the procedure easy to perform. Following treatment, blood additives are right now prepared to use.

Mirasol PRT System
Mirasol PRT Equipment

Mirasol PRT Equipment and Disposables Because Mirasol PRT may be very simple, the simplest extra device required is an illuminator. No different device is wanted for garage or mobileular washing. Currently the Mirasol PRT illuminator in improvement calls for much less than 3 linear toes of counter space.

Navigant is running intently with blood facilities to layout a PRT device that meets the dimensions and method necessities of the blood series locations. The disposable units for Mirasol PRT will range truly relying at the blood element. However the primary disposable units will encompass a bag containing the riboflavin answer and a general bag for element series/mixing/garage/ illumination. The Mirasol PRT structures beneathneath improvement for platelets and plasma are basically identical.

Inactivation Results

Mirasol PRT has been tested on a variety of pathogens implicated in transfusion transmitted diseases and has demonstrated significant pathogen load reduction. Pathogens that have been reported to be inactivated include:



  • Bovine Viral Diarrhea Virus (BVDV)
  • Human Immunodeficiency Virus–1 (HIV-1) – Extracellular and Cell Associated
  • Human Immunodeficiency Virus–1 (HIV-1) – Intracellular, Proviral
  • Pseudorabies Virus (PRV)
  • Vesicular Stomatitis Virus (VSV)
  • West Nile Virus (WNV)
  • Sindbis Virus
  • Herpes Simplex Virus-1 (HSV-1)
  • Infectious Bovine Rhinotracheitis Virus (IBR)


  • Canine Parvovirus
  • Hepatitis A Virus
  • Porcine Parvovirus Virus (PPV)
  • Encephalomyocarditis (EMC)


Gram Positive

  • B. cereus
  • S. aureus
  • S. epidermidis

Gram Negative

  • E. coli
  • K. pneumoniae
  • P. aeruginosa
  • S. marcescens


  • Plasmodium Falciparum (Malaria)
  • Orientia Tsutsugamushi


  • Graft vs. Host Disease (GvHD) – Mouse Model
  • Supression of Cytokine Production
  • Supression of White Cell Proliferation