Alternative Names/Synonyms: Actinomycin C1, Actinomycin IV, Dactinomycin
An antineoplastic antibiotic. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. A DNA-intercalator with growth inhibitory activity against certain leukemias and sarcomas. At higher concentrations, DNA polymerase is inhibited. Inhibits cell growth and colony formation in synchronized HeLa cells. A potent inducer of apoptosis in many cell lines (1).
Appearance: Red-Orange Solid
Formulation: N/A
CAS Number: 50-76-0
Structure Available: yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C62H86N12O16
Molecular Weight: 1255,5
Cell-Permeable: No
Purity: >98% by TLC
Solubility/Reconstitution Instructions: DMSO (20 mg/ml)
Shipping Conditions: gel pack
Storage Temperature: -20 Celsius
Handling: Protect from light and moisture
Shelf life: 12 months
MDL Number: MFCD00005033
PubChem CID: 2019
PubChem CID Link: Click Here
Category: Apoptosis Inducer
MSDS Available: yes
Key Words: Actinomycin D, Actinomycin IV, Actinomycin C1, Dactinomycin, RNA, polymerases, inhibitors, Antineoplastic, antibiotics, Apoptosis, Inducers, ActinomycinD
For more information, please, refer to the full datasheet.