Short Name: Anti-ZWINT
Long Name: ZWINT Primary Polyclonal Antibody
Alternative Name: ZWINT Polyclonal Antibody
Synonym Names: HZwint1; KNTC 2 AP; KNTC2AP; MGC 117174; MGC117174; ZW10 interacting protein 1; ZW10 interactor; ZWINT 1; ZWINT1; ZWINT-1; ZWINT_HUMAN.
Also Known As: ZWINT PAb
Host: Rabbit (Oryctolagus cuniculus)
Target Antigen: ZWINT
Specificity: This is a highly specific antibody against ZWINT.
Modification Sites: Unmodified antibody
Clone number: Polyclonal antibody
Isotype: Immunoglobulin G (IgG)
Concentration: 1ug per 1ul
Source: This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ZWINT
Gene ID number: 11130
Tested Applications: WB, IHC-P, IF(IHC-P)
Recommended dilutions: WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Cross reactivity: Human, Mouse, Rat
Cross reactive species details: Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the target antigen: ZWINT is a component of the MIS12 complex, which is required for kinetochore function and spindle checkpoint activity. ZWINT interacts with ZW10 and targets it to the kinetochore at prometaphase. ZWINT is detectable on the kinetochore till late anaphase. Inhibition of ZWINT expression results in chromosome missegregation, spindle checkpoint failure and, ultimately, cell death upon cytokinesis.
Purification method: This antibody was purified via Protein A.
Storage conditions: Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20шC for up to 1 year.