West Nile Virus Envelope Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. While the viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway, the highly glycosylated envelope protein plays a major role for WNV entry into target cells as this entry can be inhibited by using a recombinant domain III from the envelope glycoprotein. The WNV receptor has recently been identified as alpha v beta 3 integrin.
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
- West Nile Virus Envelope antibody can be stored at 4˚
- C for three months and -20˚
- C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Research area: Infectious Disease
- Host species: Rabbit
- Species reactivity: Virus
- Homology: N/A
- Immunogen: West Nile virus envelope antibody was raised against a synthetic peptide corresponding to 14 amino acids at the C-terminus of the West Nile Virus envelope protein.
- The immunogen is located within amino acids 740 - 790 of West Nile Virus Envelope.
- Tested Applications: E
- Applications: West Nile virus envelope protein antibody can be used for the detection of the West Nile virus envelope protein in ELISA. It will detect 10 ng of free peptide at 1 μ
- g/mL.
- Specificity: N/A
- Positive control 1: N/A
- Positive control 2: N/A
- Positive control 3: N/A
- Positive control 4: N/A
- Positive control 5: N/A
- Positive control 6: N/A
- Predicted molecular weight: N/A
- MW explanation: N/A
- Validation: N/A
- Isoforms: N/A
- Purification: West Nile Virus Envelope Antibody is affinity chromatography purified via peptide column.
- Clonality: Polyclonal
- Clone: N/A
- Isotype: IgG
- Conjugate: Unconjugated
- Physical state: Liquid
- Buffer: West Nile Virus Envelope Antibody is supplied in PBS containing 0.02% sodium azide.
- Concentration: 1 mg/mL
- NCBI official symbol: WNVgp1
- Accession #: NP_776014
- Protein GI #: 27735302
- NCBI gene ID#: 912267
- NCBI official full name: Envelope protein
- NCBI organism: West Nile virus
- SWISSPROT #: P06935
Optimal dilutions for each application to be determined by the researcher.
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