TLR1 Antibody

TLR1 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR1 is co-expressed with TLR2 on myeloid cells of the innate immune systems in lymphoid tissue such as monocytes and dendritic cells where they form heterodimers that can recognize triacylated lipoproteins.

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

• TLR1 antibody can be stored at 4˚
• C for three months and -20˚
• C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Research area: Innate Immunity
• Host species: Rabbit
• Species reactivity: Human
• Homology: N/A
• Immunogen: TLR1 antibody was raised against a peptide corresponding to 17 amino acids near the center of human TLR1.
• The immunogen is located within amino acids 390 - 440 of TLR1.
• Tested Applications: E, WB, ICC
• Applications: TLR1 antibody can be used for detection of TLR1 by Western blot at 1 to 2 μ
• g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ
• g/mL.
• Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
• Specificity: N/A
• Positive control 1: Cat. No. 1224 - Daudi Cell Lysate
• Positive control 2: Cat. No. 1208 - THP-1 Cell Lysate
• Positive control 3: N/A
• Positive control 4: N/A
• Positive control 5: N/A
• Positive control 6: N/A
• Predicted molecular weight: Predicted: 87 kDa
• Observed: 93 kDa
• MW explanation: N/A
• Validation: N/A
• Isoforms: N/A
• Purification: TLR1 Antibody is Ion exchange chromatography purified.
• Clonality: Polyclonal
• Clone: N/A
• Isotype: IgG
• Conjugate: Unconjugated
• Physical state: Liquid
• Buffer: TLR1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL
• NCBI official symbol: TLR1
• Accession #: CAG38593
• Protein GI #: 49065550
• NCBI gene ID#: 7096
• NCBI official full name: toll-like receptor 1
• NCBI organism: Homo sapiens
• SWISSPROT #: Q15399

Optimal dilutions for each application to be determined by the researcher.