RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T cell proliferation. Important regulator of interactions between T cells and dendritic cells and may play a role in the regulation of the T cell-dependent immune response. RANKL plays an important role in the progression of Breast cancer.
Stable for at least 6 months after receipt when stored at -20°C.
- Tested Applications: N/A
- Applications: This recombinant proteins is for research use only.
- Predicted Molecular Weight: N/A
- Physical state: Lyophilized
- Buffer: Contains PBS. Reconstitute with 100 µl sterile water.
- Concentration: 0.1mg/ml after reconstitution.
- NCBI official symbol: Tnfsf11
- Accession #: O35235
- Protein GI: 342187063
- NCBI gene ID#: 21943
- NCBI official full name: tumor necrosis factor (ligand) superfamily, member 11
- NCBI organism: Mus musculus
- Peptide sequence: N/A
- SWISSPROT #: O14763
- Background Reference 1: N/A
- Background Reference 2: N/A
- Background Reference 3: N/A
- Background Reference 4: N/A
- Background Reference 5: N/A
- Source: HEK293 cells
- Species: Mouse
- By Source: Human Cells
- By Species: Mouse
- Fusion tag: Fc Tag
- Sequence: Mouse RANKL (aa 157-316) is fused at the N-terminus to the Fc portion of human IgG1.
- Biology activity: Induces osteoclastogenesis of bone marrow-derived macrophages.
- Purity: >95% (SDS-PAGE).
- Endotoxin level is less than 0.01EU/ µg purified protein (LAL test
- Lonza).
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
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