PTP1B Antibody

Product Quantity: 100 ug Manufacturer: Biovision

488.75 £

Antibody Target: PTP1B

Target Alternative Name: Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B, PTP-1B, PTP1B

Tagline: 

Category: PTP1B

Host: Rabbit

Antibody Type: Polyclonal

Isotype: Rabbit IgG

Clone: 

Species Reactivity: Human

Immunogen Sequence: Synthetic peptide selected from the C-terminal region of human PTP1B

Accession: P18031

Gene ID: 5770

Appearance: Colorless liquid

Antibody Form: Liquid

Concentration: 0.25 mg/ml

Formulation: 100 ug (0.25 mg/ml) purified rabbit Ig polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Purification: Affinity purified

Application: ELISA, Western blot, Immunohistochemistry

Positive Control: 

Application & Usage: The antibody can be used for ELISA (0.25 ug/ml), Western blotting (0.5 – 2.5 ug/ml) and Immunohistochemistry (2.5 – 5.0 ug/ml).

Background Descriptions: PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

Storage Temperature: -20 Celsius

Shipping: gel pack

Shelf Life: 12 months

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use. Lyophilized and liquid form antibodies can be shipped and stored for short terms at +4 degrees Celsius and at -20 for long term storage.

Elisa: Verified

Western Blot (WB): Verified

Immunoprecipitation (IP): Not Verified

Immunofluorescence (IF): Not Verified

Flow Cytometry: Not Verified

Immunohistochemistry (IHC): Verified

Dot blot: 

ChIP: 

For more information, please, refer to the full datasheet.