As a receptor for PDGFA, PDGFR alpha promotes or inhibits cell proliferation and cell migration. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. [UniProt]
In 1X PBS, pH 7.4, with 0.09% sodium azide
Aliquot the PDGFR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Human
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