A monoclonal antibody from clone 2E11 against Human | Mouse Histone H3 (tri Methyl Lys4). The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Prepared by immunizing synthetic peptide coupled to KLH.. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:1000). This MAb for Histone H3 (tri Methyl Lys4) is conjugated with ATTO 565.
Histone H3 is a 17 kD nuclear protein that is a component of an octamer containing pairs of each of four core histones (H2A, H2B, H3, H4). The core histones create nucleosome structure of chromosomal fiber in eukaryotes and are dynamic in gene regulation. The histones exhibit cell cycle-dependent transcriptional regulation except for the variant H3.3 which is cell cycle-independent. Histone H3 can be modified by phosphorylation, acetylation, ubiquitination, ribosylation, and methylation. Histone H3 has been shown to interact with Rsk-2, MSK1, GCN5 family of HATs, HDACs, PARP, SET7/9, and CARM1. Histones play a cental role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
- Shipped on ice packs at +4ºC . Upon receiving the antibody store it at -20ºC.
- The gross weight of the package is 1.4 kg. and the net weight of the product is 0.1 grams.
- The item is not hazardous according to both ADR and UN. Its tariff code is 3002.15.0000 (Immunological products, put up in measured doses or in forms or packings for retail sale). The UNSPSC code of the product is 12352203 (Antibodies).
This product is not for human or animal treatment or consumption. Not for use in diagnostics or therapeutics. For in vitro research use only.
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