IL-31 Antibody

IL-31 Antibody: Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

• IL-31 antibody can be stored at 4˚
• C for three months and -20˚
• C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Research area: Signal Transduction, Chemokines & Cytokines
• Host species: Rabbit
• Species reactivity: Mouse
• Homology: N/A
• Immunogen: IL-31 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of mouse IL-31.
• The immunogen is located within amino acids 30 - 80 of IL-31.
• Tested Applications: E, WB, IHC-P
• Applications: IL-31 antibody can be used for the detection of IL-31 by Western blot at 2.5 - 10 μ
• g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ
• g/mL.
• Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
• Specificity: N/A
• Positive control 1: Cat. No. 1283 - RAW 264.7 Cell Lysate
• Positive control 2: Cat. No. 1467 - Rat Skeletal Muscle Tissue Lysate
• Positive control 3: N/A
• Positive control 4: N/A
• Positive control 5: N/A
• Positive control 6: N/A
• Predicted molecular weight: N/A
• MW explanation: N/A
• Validation: N/A
• Isoforms: N/A
• Purification: IL-31 Antibody is affinity chromatography purified via peptide column.
• Clonality: Polyclonal
• Clone: N/A
• Isotype: IgG
• Conjugate: Unconjugated
• Physical state: Liquid
• Buffer: IL-31 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL
• NCBI official symbol: Il31
• Accession #: AAS82846
• Protein GI #: 46241139
• NCBI gene ID#: 76399
• NCBI official full name: interleukin 31
• NCBI organism: Mus musculus
• SWISSPROT #: Q6EAL8

Optimal dilutions for each application to be determined by the researcher.