Interleukin 28 (IL-28B), also known as interferon lambda 3, is cytokine distantly related to type I interferons and the IL-10 family (1). The IL-28B gene and the closely related cytokine genes IL-28A and IL-29 form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection and can induce anti-viral activity (2,3). All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor-beta (IL10RB) and interleukin 28 receptor- alpha (IL28RA) (1).
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
- IL-28B antibody can be stored at 4˚
- C for three months and -20˚
- C, stable for up to one year.
- Research area: Innate Immunity
- Host species: Rabbit
- Species reactivity: Human
- Homology: N/A
- Immunogen: IL-28B antibody was raised against a 17 amino acid peptide near the center of human IL-28B.
- The immunogen is located within amino acids 120 - 170 of IL-28B .
- Tested Applications: E, WB, IF
- Applications: IL-28B antibody can be used for detection of IL-28B by Western blot at 1 - 2 μ
- g/ml.
- Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
- Specificity: IL-28B antibody is human specific. IL-28B antibody may cross-react with IL-28A and IL-29.
- Positive control 1: Cat. No. 1201 - HeLa Cell Lysate
- Positive control 2: Cat. No. 17-001 - HeLa Cell Slide
- Positive control 3: N/A
- Positive control 4: N/A
- Positive control 5: N/A
- Positive control 6: N/A
- Predicted molecular weight: Predicted: 20 kDa
- Observed: 16kDa
- MW explanation: N/A
- Validation: N/A
- Isoforms: N/A
- Purification: IL-28B Antibody is affinity chromatography purified via peptide column.
- Clonality: Polyclonal
- Clone: N/A
- Isotype: IgG
- Conjugate: Unconjugated
- Physical state: Liquid
- Buffer: IL-28B Antibody is supplied in PBS containing 0.02% sodium azide.
- Concentration: 1 mg/mL
- NCBI official symbol: IFNL3
- Accession #: NP_742151
- Protein GI #: 28144901
- NCBI gene ID#: 282617
- NCBI official full name: interferon, lambda 3
- NCBI organism: homo sapiens
- SWISSPROT #: Q8IZI9
Optimal dilutions for each application to be determined by the researcher.
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