Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R(CRF29) and IL-10Rbeta(CRF24), belonging to the class II cytokine receptor family.
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
- Tested Applications: N/A
- Applications: This recombinant proteins is for research use only.
- Predicted Molecular Weight: N/A
- Physical state: Lyophilized
- Buffer: Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 µg/ml in sterile PBS.
- Concentration: N/A
- NCBI official symbol: IL22
- Accession #: NP_065386
- Protein GI: 10092625
- NCBI gene ID#: 50616
- NCBI official full name: interleukin 22
- NCBI organism: Homo sapiens
- Peptide sequence: N/A
- SWISSPROT #: P06179
- Background Reference 1: N/A
- Background Reference 2: N/A
- Background Reference 3: N/A
- Background Reference 4: N/A
- Background Reference 5: N/A
- Source: CHO cells
- Species: Human
- By Source: CHO Cells
- By Species: Human
- Fusion tag: Fc Tag
- Sequence: The extracellular domain of human IL-22 (aa 34-179) is fused to the N-terminus of the Fc region of human IgG1.
- Biology activity: N/A
- Purity: >98% (SDS-PAGE).
- Endotoxin level is less than 0.06EU/ µg protein (LAL test
- Lonza).
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
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