Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
- Tested Applications: E, WB
- Applications: This protein carries no "tag". The protein has a calculated MW of 12.8 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE).
- Predicted Molecular Weight: 12.8 kDa
- Physical state: Lyophilized
- Buffer: PBS, pH7.4
- Concentration: N/A
- NCBI official symbol: IL15
- Accession #: AAH18149.1
- Protein GI: N/A
- NCBI gene ID#: 3600
- NCBI official full name: interleukin 15
- NCBI organism: Homo sapiens
- Peptide sequence: N/A
- SWISSPROT #: P40933
- Background Reference 1: Grabstein KH, et al. 1994, Science 264 (5161): 965–8.
- Background Reference 2: Malamut G, et al. 2010, J. Clin. Invest. 120 (6): 2131–43.
- Background Reference 3: Klebanoff CA, et al. 2004, Proc. Natl. Acad. Sci. U.S.A. 101 (7): 1969–74.
- Background Reference 4: Teague RM, et al. 2006, Nat. Med. 12 (3): 335–41.
- Background Reference 5: N/A
- Source: E. coli
- Species: Human
- By Source: E. coli
- By Species: Human
- Fusion tag: Tag Free
- Sequence: Asn 49 - Ser 162
- Biology activity: N/A
- Purity: >95% as determined by SDS-PAGE.
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
0 reviews for ProSci