FOXP3 Antibody: FOXP3 is a member of the forkhead/winged-helix family of transcriptional regulators. FOXP3 acts as a repressor of transcription and regulates T cell activation, with its overexpression in CD4 T cells leading to an attenuation of activation-induced cytokine production and proliferation. In regulatory T (Treg) cells, FOXP3 is essential for Treg suppressor function and its expression leads to the repression of IL-17 expression. Genetic mutations involving FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome.
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
- FOXP3 antibody can be stored at 4˚
- C for three months and -20˚
- C, stable for up to one year.
- Research area: Innate Immunity
- Host species: Rabbit
- Species reactivity: Human, Mouse, Rat
- Homology: N/A
- Immunogen: Rabbit polyclonal FOXP3 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human FOXP3.
- The immunogen is located within the last 50 amino acids of FOXP3.
- Tested Applications: E, WB, IHC-P, IF
- Applications: FOXP3 antibody can be used for detection of FOXP3 by Western blot at 1 - 2 μ
- g/mL.
- Antibody validated: Western Blot in human samples
- Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
- Specificity: N/A
- Positive control 1: Cat. No. 1203 - A549 Cell Lysate
- Positive control 2: N/A
- Positive control 3: N/A
- Positive control 4: N/A
- Positive control 5: N/A
- Positive control 6: N/A
- Predicted molecular weight: Predicted: 47 kDa
- MW explanation: N/A
- Validation: N/A
- Isoforms: N/A
- Purification: FOXP3 Antibody is affinity chromatography purified via peptide column.
- Clonality: Polyclonal
- Clone: N/A
- Isotype: IgG
- Conjugate: Unconjugated
- Physical state: Liquid
- Buffer: FOXP3 Antibody is supplied in PBS containing 0.02% sodium azide.
- Concentration: 1 mg/mL
- NCBI official symbol: FOXP3
- Accession #: NP_054728
- Protein GI #: 31982943
- NCBI gene ID#: 50943
- NCBI official full name: forkhead box P3
- NCBI organism: homo sapiens
- SWISSPROT #: Q9BZS1
Optimal dilutions for each application to be determined by the researcher.
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