DcR1 Antibody

Supplier: Gentaur

0.01 GBP
Catalog: 223-2179-002mg Stock:On request
Product Size: 0.02 mg

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DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

  • DcR1 antibody can be stored at 4˚
  • C for three months and -20˚
  • C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

  • Research area: Apoptosis
  • Host species: Rabbit
  • Species reactivity: Human, Mouse, Rat
  • Homology: N/A
  • Immunogen: DcR1 antibody was raised against a peptide corresponding to amino acids in a extracellular domain of human DcR1 precursor.
  • The immunogen is located within amino acids 140 - 190 of DcR1.
  • Tested Applications: E, WB, ICC, IF
  • Applications: DcR1 antibody can be used for detection of DcR1 by Western blot 0.5 μ
  • g/mL. An approximate 65 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 μ
  • g/mL. For immunofluorescence start at 20 μ
  • g/mL.
  • Antibody validated: Western Blot in human samples
  • Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
  • Specificity: N/A
  • Positive control 1: Cat. No. 1201 - HeLa Cell Lysate
  • Positive control 2: Cat. No. 17-001 - HeLa Cell Slide
  • Positive control 3: N/A
  • Positive control 4: N/A
  • Positive control 5: N/A
  • Positive control 6: N/A
  • Predicted molecular weight: 65 kDa
  • MW explanation: N/A
  • Validation: N/A
  • Isoforms: N/A
  • Purification: DcR1 Antibody is affinity chromatography purified via peptide column.
  • Clonality: Polyclonal
  • Clone: N/A
  • Isotype: IgG
  • Conjugate: Unconjugated
  • Physical state: Liquid
  • Buffer: DcR1 Antibody is supplied in PBS containing 0.02% sodium azide.
  • Concentration: 1 mg/ml
  • NCBI official symbol: TNFRSF10C
  • Accession #: AF012536
  • Protein GI #: 2338421
  • NCBI gene ID#: 8794
  • NCBI official full name: tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
  • NCBI organism: Homo sapiens
  • SWISSPROT #: O14798

Optimal dilutions for each application to be determined by the researcher.

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