DcR1 Antibody

DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

• DcR1 antibody can be stored at 4˚
• C for three months and -20˚
• C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Research area: Apoptosis
• Host species: Rabbit
• Species reactivity: Human, Mouse, Rat
• Homology: N/A
• Immunogen: DcR1 antibody was raised against a peptide corresponding to amino acids in a extracellular domain of human DcR1 precursor.
• The immunogen is located within amino acids 140 - 190 of DcR1.
• Tested Applications: E, WB, ICC, IF
• Applications: DcR1 antibody can be used for detection of DcR1 by Western blot 0.5 μ
• g/mL. An approximate 65 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 μ
• g/mL. For immunofluorescence start at 20 μ
• g/mL.
• Antibody validated: Western Blot in human samples
• Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
• Specificity: N/A
• Positive control 1: Cat. No. 1201 - HeLa Cell Lysate
• Positive control 2: Cat. No. 17-001 - HeLa Cell Slide
• Positive control 3: N/A
• Positive control 4: N/A
• Positive control 5: N/A
• Positive control 6: N/A
• Predicted molecular weight: 65 kDa
• MW explanation: N/A
• Validation: N/A
• Isoforms: N/A
• Purification: DcR1 Antibody is affinity chromatography purified via peptide column.
• Clonality: Polyclonal
• Clone: N/A
• Isotype: IgG
• Conjugate: Unconjugated
• Physical state: Liquid
• Buffer: DcR1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• NCBI official symbol: TNFRSF10C
• Accession #: AF012536
• Protein GI #: 2338421
• NCBI gene ID#: 8794
• NCBI official full name: tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
• NCBI organism: Homo sapiens
• SWISSPROT #: O14798

Optimal dilutions for each application to be determined by the researcher.