Daxx Antibody

Product Quantity: 100 ug Manufacturer: Biovision

421.25 £

Antibody Target: Daxx

Target Alternative Name: Death domain-associated protein 6, ETS1-associated protein 1, Fas death domain-associated protein

Tagline: Polyclonal Antibody to detect Daxx in human, mouse and rat samples

Category: Daxx

Host: Rabbit

Antibody Type: Polyclonal

Isotype: Rabbit IgG

Clone: 

Species Reactivity: Human, mouse, rat

Immunogen Sequence: Synthetic peptide in the middle of the sequence (BV-M28)

Accession: Q9UER7

Gene ID: 1616

Appearance: Colorless liquid

Antibody Form: Liquid

Concentration: 0.5 mg/ml

Formulation: 100 ug (0.5 mg/ml) of antibody in PBS, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2

Purification: Affinity purified

Application: Western blot

Positive Control: Western blot: Rat Kidneylysate

Application & Usage: Western blot: 1:200

Background Descriptions: Apoptosis can be induced by certain cytokines including TNF and Fas ligand through binding to their respective death domain (DD) containing receptors, TNFR1 and Fas. Cell death signals can then be transduced by DD-containing adapter molecules and members of the caspase family. A novel DD-containing adapter molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds to the Fas DD and activates a FADD-independent death pathway that involves the stress activated c-Jun NH2-terminal kinase (JNK). Daxx activates the JNK kinase kinase ASK1 that is also known as MAPKKK5. FADD and Daxx activate two independent pathways downstream of Fas. Daxx mRNA is widely expressed in fetal and adult tissues with the highest amounts being found in the testis.

Storage Temperature: -20 Celsius

Shipping: gel pack

Shelf Life: 12 months

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use. Lyophilized and liquid form antibodies can be shipped and stored for short terms at +4 degrees Celsius and at -20 for long term storage.

Elisa: Not Verified

Western Blot (WB): Verified

Immunoprecipitation (IP): Not Verified

Immunofluorescence (IF): Not Verified

Flow Cytometry: Not Verified

Immunohistochemistry (IHC): Not Verified

Dot blot: 

ChIP: 

For more information, please, refer to the full datasheet.