CD24 may have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity.
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
- Tested Applications: E, WB
- Applications: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 5.0 kDa. The protein migrates as 19-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Predicted Molecular Weight: 5.0 kDa
- Physical state: Lyophilized
- Buffer: PBS, pH7.4
- Concentration: N/A
- NCBI official symbol: CD24
- Accession #: NP_001278666.1
- Protein GI: N/A
- NCBI gene ID#: 100133941
- NCBI official full name: CD24molecule
- NCBI organism: Homo sapiens
- Peptide sequence: N/A
- SWISSPROT #: P25063
- Background Reference 1: Suzuki T1, et al. 2001. J Immunol. 166(9):5567-77.
- Background Reference 2: Chen Z, et al. 2017. Biomed Pharmacother. 90:427-436.
- Background Reference 3: Eyvazi S, et al. 2018. Curr Cancer Drug Targets. 18(4):328-336.
- Background Reference 4: N/A
- Background Reference 5: N/A
- Source: HEK293 cells
- Species: Human
- By Source: Human Cells
- By Species: Human
- Fusion tag: His Tag
- Sequence: Ser 27 - Gly 59
- Biology activity: N/A
- Purity: >90% as determined by SDS-PAGE.
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