Alternative Names/Synonyms: 1,?2,?3,?3a-?tetrahydro-?3aS-?hydroxy-?6-?methyl-?1-?phenyl-?4H-?Pyrrolo[2,?3-?b]quinolin-?4-?one; (S)-Blebbistatin
Cell-permeable. The active enantiomer of (±)-Blebbistatin (Cat. No. 2405). A selective inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50 = 0.5-5.0 ?M), while weakly inhibiting smooth muscle myosin (IC50 = 80 ?M). Through these effects, (-)-blebbistatin reversibly blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells.
Appearance: yellow solid
Formulation: N/A
CAS Number: 856925-71-8
Structure Available: yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C18H16N2O2
Molecular Weight: 292,34
Cell-Permeable: yes
Purity: ?98% by HPLC
Solubility/Reconstitution Instructions: DMSO (~25 mg/ml)
Shipping Conditions: gel pack
Storage Temperature: -20 ?C
Handling: Protect from light and air
Shelf life: 36 months
MDL Number: MFCD08460907
PubChem CID: 5287792
PubChem CID Link: Click Here
Category: Biochemicals
MSDS Available:
Key Words: (-)-blebbistatin, non-muscle myosin II, Atpase, inhibitor, of non-muscle myosin II ATPase inhibitor
For more information, please, refer to the full datasheet.