A polyclonal antibody for TLR4 from Human | Mouse. The antibody is produced in rabbit after immunization with Human Developed against a synthetic peptide corresponding to amino acids 420-435 of human TLR4. The Antibody is tested and validated for WB, IHC, ICC/IF, FCM, FACS assays with the following recommended dilutions: WB (1:500), IHC (1:50). This TLR4 antibody is conjugated to Dylight 633.
The Toll-like receptor (TLR) family in mammal comprises a family of trans-membrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and 1L-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylo-genetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). Amount this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5). The mouse TLR4 cDNA codes for a protein consisting of 839 amino acids, with an approximate molecular weight of 90kDa (6).
- Shipped on ice packs at +4ºC. Upon receipt keep at -20ºC.
- The gross weight ( in kg) of the package is ~1.4 kg. The net weight of the product is ~0.1 grams.
- The item is not hazardous according to both ADR and UN. Its tariff code is 3002.15.0000 (Immunological products, put up in measured doses or in forms or packings for retail sale). The UNSPSC code of the product is 12352203 (Antibodies).
This product is not for human or animal treatment or consumption. Not for use in diagnostics or therapeutics. For in vitro research use only.
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