The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.
- Clonality: Monoclonal
- Host: Mouse
- Conjugation: Alexa-fluor 647
- Applications: FC
- Reactivity: NA
- Formulation: PBS 50% glycerol
- Purification: QMA Hyper D ion exchange chromatography
- Clone: 0
- Concentration: 0.5 mg/ml
- Gene: LAMP3
- Immunogen: human DC-LAMP alkaline phosphatase fusion protein
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