Anti-IL7R antibody (Alexa-fluor 546)

St John's Laboratory

353.70 £

Product ID: STJ170021

In stock

Size: 100 µg

The IL7-R consists of 2 chains, IL-7R known as CD127 and common cytokine receptor chain known as CD132. A 75 to 80kDa human IL-7 receptor has been cloned that belongs to hematopoietic cytokinereceptor super family. R34-34, raised against human leukemic pre-B cells, recognized a molecule expressed on normal B cell precursors but not on mature B cells. This antibody specifically reverted IL-7 mediated growth inhibition of leukemic BCP (normal B cells precursors) and mature T cells. IL-7R expression is dramatically influenced by cytokines and antigens. This IL-7R displays both high and low affinity for its ligand (IL-7). Inhibitory and proliferative effects of IL-7 can be mediated through the same receptor on various lineages. CD4+ memory T cells express high level of IL-7R Subsets that express it generally require it, including progenitors of T and B cells, naïve and memory T cells. (Pandrau-Garcia D et al, 1994, Blood, 83, 3613-9 Mazzucchelli R et al, Nat. Review Immunol., 2007,7, 144-54)

  • Clonality: Monoclonal
  • Host: Mouse
  • Conjugation: Alexa-fluor 546
  • Applications: IF
  • Reactivity: NA
  • Formulation: PBS 50% glycerol
  • Purification: QMA Hyper D ion exchange chromatography
  • Clone: 0
  • Concentration: 0.5 mg/ml
  • Gene: FCER2
  • Immunogen: human leukemic pre-B cells

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