The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants.
- Clonality: Polyclonal
- Host: Rabbit
- Conjugation: Unconjugated
- Applications: WB
- Reactivity: Human
- Formulation: PBS with 0.02% sodium azide, pH7.3.
- Purification: Affinity purification
- Clone: NA
- Concentration: NA
- Gene: GPSM2
- Immunogen: Human
0 reviews for St John's Laboratory