Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck's granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 1999, Eur.J.Immunol., 29:2695-2704; Valladeau J et al, 2000 Immunity, 12 : 71-81; Kashihara M et al, 1986, J.Invest.Derm., 87 :602-607 Ito T et al, 1999, J.Immunol., 163 :1409-1419 ;Saeland S & Valladeau J, CD207 (Langerin) Workshop reports 2002, Leukocyte-Typing VII, White Cell Diff Antigens, D. Mason et al, Eds, Oxford University Press:306-307)
- Clonality: Monoclonal
- Host: Mouse
- Conjugation: Alexa-fluor 546
- Applications: IF
- Reactivity: NA
- Formulation: PBS 50% glycerol
- Purification: QMA Hyper D ion exchange chromatography
- Clone: 0
- Concentration: 0.5 mg/ml
- Gene: CD207
- Immunogen: In vitro-derived human DCs from CD34+ cells in GM-CSF+TNFa
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