CD11b also known as integrin alpha-M is a protein encoded by the ITGAM gene which is approximately 127,1 kDa. CD11b is localised to the cell membrane and is involved in the MAPK-Erk pathway, apoptotic pathways, ERK signalling and integrin pathway. CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. CD11b is predominantly expressed in monocytes and granulocytes. Mutations in the ITGAM gene result in systemic Lupus Erythematosus. STJ97613 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of CD11b protein.
- Clonality: Polyclonal
- Host: Rabbit
- Conjugation: Unconjugated
- Applications: WB,ELISA
- Reactivity: Human,Mouse
- Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Clone: NA
- Concentration: 1 mg/ml
- Gene: ITGAM
- Immunogen: Synthesized peptide derived from human CD11b.
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