?2-macroglobulin (9A3) Monoclonal Antibody
Short Name: Anti-?2-macroglobulin
Long Name: ?2-macroglobulin (9A3) Monoclonal Antibody
Alternative Name: ?2-macroglobulin (9A3) Monoclonal Antibody
Synonym Names: A2MD; CPAMD5; FWP007; S863-7; Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; A2M
Also Known As: ?2-macroglobulin (9A3) Monoclonal Antibody
Conjugation: Unconjugated
Host: Mouse (Mus musculus)
Target Antigen: ?2-macroglobulin
Specificity: This is a highly specific antibody against ?2-macroglobulin.
Modifications: None
Modification Sites: Unmodified antibody
Clone number: 9A3
Isotype: Immunoglobulin G (IgG)2b ?
Concentration:
Immunogen range:
Subcellular location:
Source: ?2-macroglobulin protein purified from Human plasma
Gene ID number: 2
Swiss Prot: P01023
Tested Applications: IP
Recommended dilutions: IP (1ug)
Cross reactivity: Human
Cross reactive species details: Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the target antigen: Is able to inhibit all four classes of proteinases by a unique ‘trapping’ mechanism. This protein has a peptide stretch, called the ‘bait region’ which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Purification method: Ammonium sulfate precipitation
Storage conditions: Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20шC for up to 1 year.
