Alternative Names/Synonyms: (±)-2,2?-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene; NSC 56817; NSC 524336; BL 193; Pogosin
Isolated from cotton seeds. It causes infertility in a variety of cotton pests and spermatogenesis arrest in humans. Gossypol also has antimalarial properties, preventing the growth of P. falciparum at low micromolar concentrations. It inhibits aldose reductase (Ki = 0.5 uM).Gossypol also acts as an anticancer agent, inhibiting cell growth in various cancer cell lines, in part by blocking the anti-apoptotic functions of Bcl-2 and Bcl-xL, again at low micromolar concentrations. Also acts as a non-selective competitive inhibitor of NADH binding to LDH, with K(i) values of 1.9, 1.4, and 4.2 uM for LDH-A4, -B4, and -C4, respectively.
Appearance: yellow solid
Formulation: N/A
CAS Number: 303-45-7
Structure Available: y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C30H30O8
Molecular Weight: 518,55
Cell-Permeable: yes
Purity: ?95%
Solubility/Reconstitution Instructions: DMSO (>10 mg/ml) or EtOH (>10 mg/ml with slight warming)
Shipping Conditions: Gel pack
Storage Temperature: -20 Celsius
Handling: Protect from air and light
Shelf life: 24 months
MDL Number: MFCD00017352
PubChem CID: 3503
PubChem CID Link: Click Here
Category: Biochemicals
MSDS Available:
Key Words: Gossypol, (-)-Gossypol, (+)-Gossypol, 303-45-7, Tash 1, Pogosin, racemic-Gossypol, (+-)-Gossypol, (+/-)-Gossypol, AT101, anticancer agent, LDH inhibitor, lactate dehydrogenase inhibitor
For more information, please, refer to the full datasheet.