(±)-Gossypol

Product Quantity: 50 mg Manufacturer: Biovision

178.25 £

Alternative Names/Synonyms: (±)-2,2?-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene; NSC 56817; NSC 524336; BL 193; Pogosin

Isolated from cotton seeds. It causes infertility in a variety of cotton pests and spermatogenesis arrest in humans. Gossypol also has antimalarial properties, preventing the growth of P. falciparum at low micromolar concentrations. It inhibits aldose reductase (Ki = 0.5 uM).Gossypol also acts as an anticancer agent, inhibiting cell growth in various cancer cell lines, in part by blocking the anti-apoptotic functions of Bcl-2 and Bcl-xL, again at low micromolar concentrations. Also acts as a non-selective competitive inhibitor of NADH binding to LDH, with K(i) values of 1.9, 1.4, and 4.2 uM for LDH-A4, -B4, and -C4, respectively.

Appearance: yellow solid

Formulation: N/A

CAS Number: 303-45-7

Structure Available: y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C30H30O8

Molecular Weight: 518,55

Cell-Permeable: yes

Purity: ?95%

Solubility/Reconstitution Instructions: DMSO (>10 mg/ml) or EtOH (>10 mg/ml with slight warming)

Shipping Conditions:  Gel pack

Storage Temperature: -20 Celsius

Handling: Protect from air and light

Shelf life: 24 months

MDL Number: MFCD00017352

PubChem CID: 3503

PubChem CID Link: Click Here

Category: Biochemicals

MSDS Available: 

Key Words: Gossypol, (-)-Gossypol, (+)-Gossypol, 303-45-7, Tash 1, Pogosin, racemic-Gossypol, (+-)-Gossypol, (+/-)-Gossypol, AT101, anticancer agent, LDH inhibitor, lactate dehydrogenase inhibitor

For more information, please, refer to the full datasheet.